Investigating the Selectivity of Metalloenzyme Inhibitors

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Antibiotic resistance in bacteria: novel metalloenzyme inhibitors.

Beta-lactam antibiotics are among the most important drugs used to fight bacterial infection. Overuse and misuse of beta-lactam antibiotics has caused the evolution of resistance mechanisms, allowing pathogenic bacteria to survive antibiotic treatment. The major source of resistance to beta-lactam antibiotics occurs through production of enzymes called beta-lactamases capable of catalyzing hydr...

متن کامل

investigating the feasibility of a proposed model for geometric design of deployable arch structures

deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...

the evaluation of language related engagment and task related engagment with the purpose of investigating the effect of metatalk and task typology

abstract while task-based instruction is considered as the most effective way to learn a language in the related literature, it is oversimplified on various grounds. different variables may affect how students are engaged with not only the language but also with the task itself. the present study was conducted to investigate language and task related engagement on the basis of the task typolog...

15 صفحه اول

On the selectivity of neuronal NOS inhibitors

BACKGROUND AND PURPOSE Isoform-selective inhibitors of NOS enzymes are desirable as research tools and for potential therapeutic purposes. Vinyl-l-N-5-(1-imino-3-butenyl)-l-ornithine (l-VNIO) and N(ω) -propyl-l-arginine (NPA) purportedly have good selectivity for neuronal over endothelial NOS under cell-free conditions, as does N-[(3-aminomethyl)benzyl]acetamidine (1400W), which is primarily an...

متن کامل

investigating the translation expectancy norms of iranian college student readership in terms of english fiction in persian

مفهوم هنجار برای اولین بار توسط دانشمندی به نام گیدون توری در اواخر دهه 70 مطرح شد. هنجارها توسط محققان مختلفی طبقه بندی شده اند؛ نوع هنجاری که در این تحقیق مورد بحث است "هنجار انتظارات" است. مطالعات ترجمه یک رشته ی نوپا و مستقل است که هنوز به رشد کامل خود نرسیده و بسیاری از شاخه های آن نیاز به پژوهش دارند. یکی ازاین حوزه ها که نیاز به پژوهش دارند، هنجارهای ترجمه هستند به ویژه هنجارهای انتظارات...

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Medicinal Chemistry

سال: 2013

ISSN: 0022-2623,1520-4804

DOI: 10.1021/jm401053m